The Grover Lab
UNC Blood Research Center
The University of North Carolina at Chapel Hill
ABOUT
Our laboratory's research is aimed at identifying novel mechanisms responsible for pathological activation of coagulation and venous thromboembolism. Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, is a common cardiovascular disease that is a major source of morbidity and mortality worldwide. The mechanisms that drive pathological activation of coagulation and venous thrombosis remain incompletely understood. We contend that a better understanding of these mechanisms will enable identification of at risk populations and novel targets for the development of safe and effective anticoagulants. We are currently exploring the role of C1-inhibitor, an endogenous inhibitor of multiple intrinsic pathway coagulation factors, as an important negative regulator of coagulation and venous thrombosis.
RESEARCH AREAS
NEWS
05/11/2023: Our recent publication on C1 inhibitor deficiency and thrombosis has been highlighted in an editorial by David Gailani
05/05/2023: Steven Grover presents at the 13th C1-inhibitor Deficiency & Angioedema Workshop in Budapest, Hungary
04/03/2023: The Grover Lab publishes on the association between plasma C1 inhibitor levels and venous thromboembolism in JTH
03/22/2023: Steven Grover presents at the inaugural Immunothrombosis Symposium in Munich, Germany hosted by the LMU Center for Advanced Sciences
02/08/2023: The Grover Lab's ASH Plenary highlighted in the Hematologist
01/30/2023: Our recent Blood paper has been highlighted in Hematopoiesis News and Rare Disease Advisor
01/26/2023: The Grover Lab publishes on enhanced coagulation and venous thrombosis associated with C1 inhibitor deficiency in mice in Blood