The Grover Lab

ABOUT

Our laboratory's research is aimed at identifying novel mechanisms responsible for pathological activation of coagulation and venous thromboembolism. Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, is a common cardiovascular disease that is a major source of morbidity and mortality worldwide. The mechanisms that drive pathological activation of coagulation and venous thrombosis remain incompletely understood. We contend that a better understanding of these mechanisms will enable identification of at risk populations and novel targets for the development of safe and effective anticoagulants. We are currently exploring the role of C1-inhibitor, an endogenous inhibitor of multiple intrinsic pathway coagulation factors, as an important negative regulator of coagulation and venous thrombosis.

RESEARCH AREAS

• C1-inhibitor and Venous Thrombosis

• The Intrinsic Pathway in Hemostasis and Thrombosis

NEWS

• 05/11/2025: Steven Grover presents at Versiti Blood Research Institute

• 08/20/2024: The Grover Lab receives its first R01 award from NHLBI

• 08/15/2024: Recent Blood article featured in an editorial

• 07/27/2024: Linda Sundler Björkman publishes on association between HAE and VTE in Blood

• 05/17/2024: Steven Grover wins the Brinkhous Prize at AHA Vascular Discovery

• 04/09/2024: The Grover Lab publishes on a FXII independent function of plasma kallikrein in Blood Advances

• More